Construction of the Invoicing Process through Process Mining and Business Intelligence in the Colombian Pharmaceutical Sector

The invoicing process is critical to the financial management of organizations.However, modeling this process presents challenges such as data Lamp updating, information availability, and aligning planned activities with the actual execution of the process.One difficulty is that designing the invoicing process requires extensive knowledge of the ac

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Effects of aging on the biomechanical properties of the lung extracellular matrix: dependence on tissular stretch

Introduction: Aging induces functional and structural changes in the lung, characterized by a decline in elasticity and diminished pulmonary remodeling and regenerative capacity.Emerging evidence suggests that most biomechanical alterations in the lung result from changes in the composition of the lung extracellular matrix (ECM), potentially modula

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Targeting DNA hypermethylation: Computational modeling of DNA demethylation treatment of acute myeloid leukemia

In acute myeloid leukemia (AML) DNA hypermethylation of gene promoters is frequently observed and often correlates with a block of differentiation.Treatment of AML patients with DNA methyltransferase inhibitors results in global hypomethylation of genes and, thereby, can lead to a reactivation of the differentiation capability.Unfortunately, after

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